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The UK medicines regulator says there is a small risk of severe acute pancreatitis reported with GLP‑1 weight‑loss medications and has updated guidance after an increase in reports to the Yellow Card scheme.

A new study published in Science reports that about 50% of the variation in human lifespan could be attributed to genetics after accounting for deaths from external causes. The researchers used a model calibrated with historical twin records and data on siblings of centenarians to separate extrinsic mortality from biological ageing.

NASA released interior images of the Orion capsule, which will carry four astronauts for a 10-day Artemis II mission and includes a compact lavatory and an exercise device.

East Sussex Fire and Rescue thanked residents after a series of Christmas events raised several thousand pounds for The Fire Fighters Charity, including in excess of £7,500 at Eastbourne and £4,542.32 at Preston Circus in Brighton.

Emergency services were called to Hopton early on Saturday and a 15-year-old girl later died; two 18-year-olds have been charged with supplying MDMA, remanded in custody and are due to appear at Norwich Crown Court on 25 February.

Jofra Archer is in England's XI for the first T20 against Sri Lanka in Kandy after recovering from a side strain; Ben Duckett misses out with a bruised finger and Jos Buttler will open.

Emma Raducanu has split with coach Francisco Roig after six months and will begin looking for a new coach; she has worked with nine different coaches since her Wimbledon run in 2024.

A new study reports that ditches and canals are widespread hotspots of methane and nitrous oxide and describes management options — such as reduced nutrient inputs, vegetation buffers, dredging and floating plants — that can lower emissions.

A West Lothian woman says she was 'sobbing with joy' after a maternal-assisted Caesarean at University Hospital Wishaw, reported as the first time the procedure has been used in Scotland.

Reports say Russia has agreed to a partial ceasefire that would halt attacks on Ukrainian cities for one week; further details and verification were not included in the initial report.

Edgar Barrera has been nominated again for the 2026 Grammy songwriter of the year, non-classical; if he wins he would be the first Latino to receive that honor.

Bryony Gordon describes a long struggle with bulimia and later recovery, and says the diet culture that helped trap her in the 1990s still exists today, sometimes appearing in the form of weight‑loss injections that users report cause intense hunger when stopped.

Six people died when a Bombardier Challenger 650 crashed during takeoff from Bangor International Airport, and the FAA and NTSB have opened investigations; one of the victims was Tara Arnold, the wife of a Houston lawyer.

Floods in Mozambique have flooded more than 150,000 homes and killed at least 22 people, while aid agencies say donor funding is far short of the $187 million the UN says is required for the response.

Researchers at Chalmers University used machine learning to identify short-lived blood markers tied to early Parkinson's, and the team says the findings could lead to a clinical test within about five years.

A local listings roundup details exhibitions, family attractions, fundraising events, cinema screenings and theatre performances across West Norfolk for the coming week.

US firm LanzaTech plans a £600m investment at Saltend Chemicals Park to produce sustainable aviation fuel and renewable diesel, with construction expected to begin in 2027 and operations in 2030.

In Januarys 2011, 2016 and 2018 local people, schools and groups raised funds and made donations to charities and community services, with notable contributions including £2,300 for East Anglian Children's Hospices and a £550 donation to Cancer Research UK.

Researchers measured 770 adult polar bears in Svalbard between 1992 and 2019 and found body condition increased even as regional sea ice declined; the study was published in Scientific Reports.

Surgeons at Northwestern University report a 33-year-old man with severe lung damage was sustained on a temporary artificial lung for two days until donor lungs became available, and he later received a double lung transplant and has since returned to daily life.

Sheffield's Legends Walk of Fame will add six new names, including members of Pulp, the late referee Uriah Rennie and fundraiser John Burkhill; Rennie's plaque is due to be unveiled on 2 February.

An Estyn inspection praised Ysgol Treganna in Canton for its caring, inclusive community, strong leadership and high‑quality Welsh language provision; inspectors reported most of the 659 pupils make good progress and that wellbeing support is a standout strength.

Around 850 native trees were planted using the Miyawaki method on Pendle Council land beside the Spring Mill development in Earby, with local primary pupils taking part in the planting.

The Princess Royal visited Peterborough Volunteer Fire Brigade on Wednesday, January 28, to mark the brigade's 140th anniversary, meeting serving and former firefighters and touring the station. She viewed vintage engines, a graffiti mural by Nathan Murdoch and the brigade's fundraising Santa sleigh.

Researchers from the British Antarctic Survey and the Korea Polar Research Institute are drilling about 1,000 metres into the Thwaites Glacier to observe how warm ocean water and large under-ice waves affect the ice; scientists say the glacier's collapse could raise global sea levels by about 65 centimetres.

João Palhinha said Tottenham's 2-0 win at Eintracht Frankfurt secured Champions League last-16 qualification and he expects that uplift to help improve their poor Premier League form.

Explosions and reports of gunfire were heard near Niamey airport shortly before midnight, and security sources described the incident as a "terrorist attack" while saying a store of uranium yellowcake at the airport was not affected.

Santander plans to close 44 UK branches while the article reports the bank is promoting customer account offers described as up to £225, and it says 96% of customers use digital services.

Yerin Ha, who plays Sophie Baek in Bridgerton season four, described her character's storyline as a 'Cinderella' story and said the role felt like a gift; four episodes of the season were released on Netflix on January 29 with four more due on February 26.

A Great Ormond Street Hospital review concluded that 94 children were harmed by orthopaedic surgeon Yaser Jabbar between 2017 and 2022, including 36 who suffered severe harm. The surgeon is understood to live abroad and no longer holds a UK licence.